Dermatology
The project aims to develop a tissue reconstruction therapy to promote wound healing and skin regeneration with applications in Emergency Medicine, Dermatology and Surgery.
This is a project funded by Belgian authorities.
Although many products are currently available to treat severe wounds, existing therapies are still inadequate in many cases, and mesenchymal stem cells are an attractive alternative to promote regeneration. The exogenous application of stem cells for wound healing can be considered a promising solution because of their intrinsic capacity to self-renew and differentiate into various tissues. The use of stem cells in wound healing is clinically relevant, especially for lesions that are difficult to heal, such as lesions resulting from diabetes, major trauma, vascular insufficiency, severe and extensive burns and numerous other conditions.
Mesenchymal stem cells play an important role in the remodeling of wound healing, through release of paracrine factors with potential to promote repair of tissue damage or injury and to accelerate recovery. These paracrine effects are described as immunomodulating, anti-apoptotic, pro-angiogenic, chemo-attractor, anti-fibrotic and supporting of endogenous stem cell growth and differentiation. The presence of mesenchymal stem cells at the site of injury directs regeneration and restoration of functional homeostasis.
This therapeutic approach constitutes a new allogenic stem cell therapy product for the treatment of atopic dermatitis and other skin lesions. It is an advanced biotechnology therapeutic approach, utilizing bioxomes derived from human Adipose Derived Mesenchymal Stem Cells. Bioxomes are extracellular lipid vesicles that act as targeted delivery-vehicles loaded with the therapeutic cargo of choice and enriched with selected factors that promote their therapeutic effect.
The program will utilise a number of in vitro and in vivo models to complete the pre-clinical development of a therapeutic approach that will be easily translated for safe and effective clinical application.
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